Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 7/20 | 0.47 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | CHUK | O15111 | 2/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.40 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.38 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.37 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.37 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.36 |
| ▸ | CDC42BPA | Q5VT25 | 2/20 | 0.36 |
| ▸ | CDC42BPB | Q9Y5S2 | 2/20 | 0.36 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30899087 | 1.00 | LRRK2 (0.47) | LRRK2CSNK1A1CLK4CHUKDYRK1A | |
| SCHEMBL31586107 | 0.79 | LRRK2 (0.47) | LRRK2CHUKCCNT1CDK9HASPIN | |
| SCHEMBL25401085 | 0.79 | CHUK (0.51) | LRRK2CHUK | |
| SCHEMBL22518633 | 0.76 | RPS6KA5 (0.45) | LRRK2RPS6KA5TYRO3DYRK1B | |
| SCHEMBL26638109 | 0.76 | LRRK2 (0.44) | LRRK2CHUKCCNT1CDK9HASPIN | |
| SCHEMBL21274452 | 0.74 | LRRK2 (0.53) | LRRK2CHUKDYRK1ACCNT1CDK9 | |
| SCHEMBL12120921 | 0.73 | TYRO3 (0.42) | HASPINRPS6KA5TYRO3DYRK1B | |
| SCHEMBL18009669 | 0.73 | RPS6KA5 (0.40) | RPS6KA5TYRO3DYRK1B | |
| SCHEMBL30475606 | 0.73 | TYRO3 (0.42) | HASPINRPS6KA5TYRO3DYRK1B | |
| SCHEMBL14842412 | 0.73 | AXL (0.47) | CCNT1CDK9HASPINRPS6KA5TYRO3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109311896-A | Pyrazolopyrimidine derivatives as kinase inhibitors | 株式会社大熊制药 | 2019-02-05 | — | — | CN | disclosed |