Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Merimepodib. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH1 known ✓ | P20839 | 6/20 | 0.83 |
| ▸ | IMPDH2 | P12268 | 17/20 | 0.83 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Merimepodib SCHEMBL329922 | 0.91 | IMPDH2 (1.00) | IMPDH2IMPDH1AAK1 | |
| Merimepodib SCHEMBL29591763 | 0.91 | IMPDH2 (1.00) | IMPDH2IMPDH1AAK1 | |
| Merimepodib SCHEMBL329923 | 0.91 | IMPDH2 (1.00) | IMPDH2IMPDH1AAK1 | |
| Merimepodib SCHEMBL29376593 | 0.91 | IMPDH2 (1.00) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL1472878 | 0.87 | IMPDH2 (1.00) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL1472876 | 0.87 | IMPDH2 (1.00) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL1473608 | 0.87 | IMPDH2 (0.90) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL1473611 | 0.87 | IMPDH2 (0.90) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL12938851 | 0.85 | IMPDH2 (0.87) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL12300719 | 0.84 | IMPDH2 (0.80) | IMPDH2IMPDH1AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109310678-A | The combination preparation of three kinds of antiviral compounds | 吉利德制药有限责任公司 | 2019-02-05 | — | — | CN | disclosed |