Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 16/20 | 0.51 |
| ▸ | HSD11B2 | P80365 | 12/20 | 0.51 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2826897 | 0.92 | HSD11B1 (0.51) | HSD11B1HSD11B2P2RX7 | |
| SCHEMBL2822046 | 0.91 | HSD11B1 (0.64) | HSD11B1HSD11B2 | |
| SCHEMBL2822509 | 0.86 | HSD11B1 (0.52) | HSD11B1HSD11B2P2RX7SIGMAR1 | |
| SCHEMBL2824842 | 0.86 | HSD11B1 (0.51) | HSD11B1HSD11B2 | |
| SCHEMBL2822279 | 0.85 | HSD11B1 (0.61) | HSD11B1HSD11B2 | |
| SCHEMBL2825188 | 0.85 | HSD11B1 (0.50) | HSD11B1HSD11B2 | |
| SCHEMBL2827319 | 0.85 | HSD11B1 (0.50) | HSD11B1HSD11B2 | |
| SCHEMBL2827662 | 0.84 | HSD11B1 (0.61) | HSD11B1HSD11B2 | |
| SCHEMBL2827659 | 0.84 | HSD11B1 (0.61) | HSD11B1HSD11B2 | |
| SCHEMBL2827453 | 0.83 | HSD11B1 (0.50) | HSD11B1HSD11B2P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2243479-A2 | Novel amide and amidine derivates and uses thereof | Abbott Laboratories (US) | 2010-10-27 | — | — | EP | claimed |
| EP-2243479-A2 | Novel amide and amidine derivates and uses thereof | Abbott Laboratories (US) | 2010-10-27 | — | — | EP | disclosed |