Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | TSHR | P16473 | 5/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2827626 | 0.95 | SMN1; SMN2 (0.47) | SMN1; SMN2TSHROPRM1OPRD1ALDH1A1 | |
| SCHEMBL2829065 | 0.90 | SMN1; SMN2 (0.49) | SMN1; SMN2TSHROPRM1OPRD1ALDH1A1 | |
| SCHEMBL2830858 | 0.87 | SMN1; SMN2 (0.58) | SMN1; SMN2TSHROPRM1OPRD1ALDH1A1 | |
| SCHEMBL2829170 | 0.87 | SMN1; SMN2 (0.46) | SMN1; SMN2TSHROPRM1OPRD1ALDH1A1 | |
| SCHEMBL2831312 | 0.86 | SMN1; SMN2 (0.49) | SMN1; SMN2TSHROPRM1OPRD1ALDH1A1 | |
| SCHEMBL14237613 | 0.86 | SMN1; SMN2 (0.48) | SMN1; SMN2TSHROPRM1OPRD1ALDH1A1 | |
| SCHEMBL2827673 | 0.85 | SMN1; SMN2 (0.47) | SMN1; SMN2TSHROPRM1OPRD1ALDH1A1 | |
| SCHEMBL2826460 | 0.85 | SMN1; SMN2 (0.47) | SMN1; SMN2TSHROPRM1OPRD1ALDH1A1 | |
| SCHEMBL2828078 | 0.85 | ALDH1A1 (0.49) | SMN1; SMN2TSHROPRM1OPRD1ALDH1A1 | |
| SCHEMBL2848590 | 0.85 | SMN1; SMN2 (0.47) | SMN1; SMN2TSHROPRM1OPRD1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2620150-A2 | 2-Amido Thiazole Based Inhibitors of ATP-Utilizing Enyzmes | Genentech, Inc. (US) | 2013-07-31 | — | — | EP | disclosed |
| EP-2168578-B1 | Thiazole based inhibitors of ATP-utilizing enzymes | GENENTECH INC (US) | 2012-12-19 | — | — | EP | disclosed |
| EP-2168578-A2 | 2-Amido-Thiazole-Based Compounds Exhibiting ATP-Utilizing Enzyme Inhibitory Activity, and Compositions, and Uses Thereof | Genentech, Inc. (US) | 2010-03-31 | — | — | EP | disclosed |