SCHEMBL28280359

SCHEMBL28280359

N#CC(C(N)=O)(c1ccccc1)C(F)(F)F

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.46
KMT2A Q03164 1/20 0.46
KCNN4 O15554 9/20 0.44
HTT P42858 1/20 0.42
PTPN1 P18031 1/20 0.38
KCNE1 P15382 1/20 0.38
KCNQ1 P51787 1/20 0.38
CA1 P00915 1/20 0.37
CA2 P00918 1/20 0.37
CA5A P35218 1/20 0.37
CA9 Q16790 1/20 0.37
TSHR P16473 2/20 0.37
ALDH1A1 P00352 1/20 0.37
MCL1 Q07820 1/20 0.36
CYP1A2 P05177 2/20 0.35
CES1 P23141 1/20 0.35
POLB P06746 1/20 0.34
CYP3A4 P08684 1/20 0.34
PARP1 P09874 1/20 0.34
CYP2C19 P33261 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15155395 0.79 MAPT (0.47) MAPTKMT2AKCNN4HTTPTPN1
SCHEMBL9436366 0.76 CYP1A2 (0.48) MAPTKMT2AKCNN4HTTPTPN1
SCHEMBL10615654 0.75 MAPT (0.50) MAPTKMT2AKCNN4HTTKCNE1
SCHEMBL15559997 0.72 MAPT (0.57) MAPTKMT2AKCNN4HTTTSHR
SCHEMBL4245525 0.71 MAPT (0.56) MAPTKMT2AKCNN4HTTPTPN1
SCHEMBL5709190 0.71 KCNN4 (0.46) MAPTKMT2AKCNN4PTPN1CA1
SCHEMBL17968493 0.71 MAPT (0.56) MAPTKMT2AKCNN4HTTPTPN1
SCHEMBL2465581 0.71 MAPT (0.56) MAPTKMT2AKCNN4HTTPTPN1
SCHEMBL29356349 0.71 CYP1A2 (0.43) MAPTKMT2AKCNN4HTTPTPN1
SCHEMBL2398996 0.71 MAPT (0.50) MAPTKMT2AKCNN4HTTPTPN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105646120-B A kind of preparation method of carboxylic acid 浙江省诸暨合力化学对外贸易有限公司 2019-03-19 CN disclosed