SCHEMBL9436366

SCHEMBL9436366

N#CC(C(=O)O)(c1ccccc1)C(C#N)(C(=O)O)c1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.48
ALDH1A1 P00352 1/20 0.44
TSHR P16473 1/20 0.44
CYP2D6 P10635 3/20 0.41
MAPT P10636 1/20 0.40
KMT2A Q03164 1/20 0.40
KCNN4 O15554 3/20 0.39
CYP2C9 P11712 1/20 0.39
CYP2C19 P33261 1/20 0.39
HIF1A Q16665 1/20 0.39
ATM Q13315 1/20 0.38
KEAP1 Q14145 1/20 0.38
NFE2L2 Q16236 1/20 0.38
HDAC3 O15379 1/20 0.38
HDAC4 P56524 1/20 0.38
HDAC1 Q13547 1/20 0.38
HDAC7 Q8WUI4 1/20 0.38
HDAC2 Q92769 1/20 0.38
HDAC10 Q969S8 1/20 0.38
HDAC11 Q96DB2 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28739411 0.87 KMT2A (0.44) CYP1A2ALDH1A1TSHRCYP2D6MAPT
SCHEMBL9734276 0.81 ALDH1A1 (0.40) CYP1A2ALDH1A1TSHRCYP2D6MAPT
SCHEMBL4592713 0.81 CYP1A2 (0.48) CYP1A2ALDH1A1TSHRCYP2D6MAPT
SCHEMBL11021443 0.78 CYP1A2 (0.43) CYP1A2ALDH1A1CYP2D6CYP2C9CYP2C19
SCHEMBL3652411 0.77 CYP1A2 (0.45) CYP1A2ALDH1A1TSHRCYP2D6MAPT
SCHEMBL11460269 0.77 KCNN4 (0.60) ALDH1A1TSHRMAPTKMT2AKCNN4
SCHEMBL9513525 0.76 MAPT (0.45) CYP1A2ALDH1A1TSHRCYP2D6MAPT
SCHEMBL29356349 0.76 CYP1A2 (0.43) CYP1A2ALDH1A1TSHRCYP2D6MAPT
SCHEMBL28280359 0.76 MAPT (0.46) CYP1A2ALDH1A1TSHRCYP2D6MAPT
SCHEMBL6283925 0.73 PIN1 (0.50) ALDH1A1TSHRMAPTKMT2AKCNN4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0621886-A1 CROSSLINKING OF RUBBERS WITH ENGINEERING PLASTICS Akzo Nobel N.V. (NL) 1994-11-02 EP disclosed
WO-1993014155-A1 CROSSLINKING OF RUBBERS WITH ENGINEERING PLASTICS AKZO NOBEL N.V. (NL) 1993-07-22 WO disclosed