Known targets — ChEMBL curated mechanism
SLC6A2SLC6A3SSTR1SSTR2SSTR3SSTR5
The experimentally established mechanism targets of Aspartic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.38 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.36 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.36 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.36 |
| ▸ | GRM8 | O00222 | 1/20 | 0.36 |
| ▸ | GRM6 | O15303 | 1/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.36 |
| ▸ | GSR | P00390 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.36 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.36 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.36 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.36 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aspartic Acid SCHEMBL5604709 | 0.97 | SLC22A6 (0.39) | SLC22A6GABRR1LMNATDP1GRIK1 | |
| Aspartic Acid SCHEMBL162426 | 0.97 | SLC22A6 (0.39) | SLC22A6GABRR1LMNATDP1GRIK1 | |
| Aspartic Acid SCHEMBL20454596 | 0.95 | SLC22A6 (0.38) | SLC22A6GABRR1LMNATDP1GRIK1 | |
| Aspartic Acid SCHEMBL10599250 | 0.95 | SLC22A6 (0.38) | SLC22A6GABRR1LMNATDP1GRIK1 | |
| Aspartic Acid SCHEMBL5160188 | 0.95 | SLC22A6 (0.38) | SLC22A6GABRR1LMNATDP1GRIK1 | |
| Aspartic Acid SCHEMBL5195845 | 0.95 | SLC22A6 (0.38) | SLC22A6GABRR1LMNATDP1GRIK1 | |
| Aspartic Acid SCHEMBL3976768 | 0.95 | SLC22A6 (0.38) | SLC22A6GABRR1LMNATDP1GRIK1 | |
| Aspartic Acid SCHEMBL17747944 | 0.95 | SLC22A6 (0.38) | SLC22A6GABRR1LMNATDP1GRIK1 | |
| Aspartic Acid SCHEMBL17350094 | 0.95 | SLC22A6 (0.38) | SLC22A6GABRR1LMNATDP1GRIK1 | |
| Aspartic Acid SCHEMBL3413410 | 0.95 | SLC22A6 (0.38) | SLC22A6GABRR1LMNATDP1GRIK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1745791-A2 | Treating cartilage/bone conditions with water-soluble strontium salts | Osteologix A/S (DK) | 2007-01-24 | — | — | EP | claimed |
| US-20060122274-A1 | Water-soluble strontium salts for use in treatment of cartilage and/or bone conditions | OSTEOLOGIX A/S (DK) | 2006-06-08 | — | — | US | claimed |
| EP-1534305-A2 | TREATING CARTILAGE / BONE CONDITIONS WITH WATER-SOLUBLE STRONTIUM SALTS | Osteologix A/S (DK) | 2005-06-01 | — | — | EP | claimed |
| WO-2004098619-A2 | TREATING CARTILAGE / BONE CONDITIONS WITH WATER-SOLUBLE STRONTIUM SALTS | OSTEOLOGIX A/S (DK) | 2004-11-18 | — | — | WO | claimed |
| US-8623422-B2 | Combination treatment with strontium for the prophylaxis and/or treatment of cartilage and/or bone conditions | OSTEOLOGIX A/S (DK) | 2014-01-07 | — | — | US | disclosed |
| US-8541471-B2 | Water-soluble strontium salts for use in treatment of cartilage and/or bone conditions | OSTEOLOGIX A/S (DK) | 2013-09-24 | — | — | US | disclosed |
| EP-1622629-B1 | Controlled-release composition containing a strontium salt | OSTEOLOGIX AS (DK) | 2013-07-10 | — | — | EP | disclosed |
| EP-2266585-B1 | Water-soluble strontium salts for use in treatment of cartilage and/or bone conditions | OSTEOLOGIX AS (DK) | 2013-06-26 | — | — | EP | disclosed |
| EP-1745791-B1 | Treating cartilage/bone conditions with water-soluble strontium salts | OSTEOLOGIX AS (DK) | 2013-06-26 | — | — | EP | disclosed |
| US-20130071496-A1 | CONTROLLED RELEASE COMPOSITION CONTAINING A STRONTIUM SALT | OSTEOLOGIX A/S (DK) | 2013-03-21 | — | — | US | disclosed |
| EP-2266584-B1 | Composition with strontium and vitamin D for the prophylaxis and/or treatment of cartilage and/or bone conditions | OSTEOLOGIX AS (DK) | 2012-09-05 | — | — | EP | disclosed |
| EP-1622630-B1 | STRONTIUM COMBINATIONS FOR THE PROPHYLAXIS/TREATMENT OF CARTILAGE AND/OR BONE CONDITIONS | OSTEOLOGIX AS (DK) | 2012-08-29 | — | — | EP | disclosed |
| US-20060122274-A1 | Water-soluble strontium salts for use in treatment of cartilage and/or bone conditions | OSTEOLOGIX A/S (DK) | 2006-06-08 | — | — | US | disclosed |
| EP-1622630-A2 | STRONTIUM COMBINATIONS FOR THE PROPHYLAXIS/TREATMENT OF CARTILAGE AND/OR BONE CONDITIONS | Osteologix A/S (DK) | 2006-02-08 | — | — | EP | disclosed |
| EP-1622629-A2 | CONTROLLED RELEASE COMPOSITION CONTAINING A STRONTIUM SALT | Osteologix A/S (DK) | 2006-02-08 | — | — | EP | disclosed |
| WO-2005108339-A2 | HIGH YIELD AND RAPID SYNTHESES METHODS FOR PRODUCING METALLO-ORGANIC SALTS | OSTEOLOGIX A/S (DK) | 2005-11-17 | — | — | WO | disclosed |
| EP-1534305-A2 | TREATING CARTILAGE / BONE CONDITIONS WITH WATER-SOLUBLE STRONTIUM SALTS | Osteologix A/S (DK) | 2005-06-01 | — | — | EP | disclosed |
| WO-2004098619-A2 | TREATING CARTILAGE / BONE CONDITIONS WITH WATER-SOLUBLE STRONTIUM SALTS | OSTEOLOGIX A/S (DK) | 2004-11-18 | — | — | WO | disclosed |
| WO-2004098618-A2 | STRONTIUM COMBINATIONS FOR PROPHYLAXIS/TREATMENT OF CARTILAGE AND/OR BONE CONDITIONS | OSTEOLOGIX A/S (DK) | 2004-11-18 | — | — | WO | disclosed |
| WO-2004098617-A2 | CONTROLLED RELEASE COMPOSITION CONTAINING A STRONTIUM SALT | OSTEOLOGIX A/S (DK) | 2004-11-18 | — | — | WO | disclosed |