⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28283698 | 0.75 | — | — | |
| SCHEMBL261619 | 0.66 | ADORA3 (0.34) | — | |
| SCHEMBL12324882 | 0.66 | — | — | |
| SCHEMBL10330901 | 0.62 | GRM5 (0.41) | — | |
| SCHEMBL13357783 | 0.62 | GRM5 (0.41) | — | |
| SCHEMBL261696 | 0.62 | GRM5 (0.41) | — | |
| SCHEMBL13068654 | 0.60 | APOBEC3A (0.33) | — | |
| SCHEMBL261381 | 0.60 | GPBAR1 (0.39) | — | |
| SCHEMBL28799023 | 0.59 | — | — | |
| SCHEMBL14494876 | 0.59 | GAA (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110433162-A | It can be used as the dihydronaphthridine and related compound of the kinase inhibitor for treating proliferative disease | DECIPHERA PHARMACEUTICALS LLC | 2019-11-12 | — | — | CN | disclosed |
| CN-110403938-A | It can be used as the dihydronaphthridine and related compound of the kinase inhibitor for treating proliferative disease | DECIPHERA PHARMACEUTICALS LLC | 2019-11-05 | — | — | CN | disclosed |
| CN-104902895-B | Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases | 德西费拉制药有限责任公司 | 2019-03-29 | — | — | CN | disclosed |