Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 10/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HSD11B2 | P80365 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2823863 | 0.81 | HSD11B1 (0.48) | HSD11B1KDM4EMAPTALDH1A1HSD11B2 | |
| SCHEMBL2831590 | 0.81 | HSD11B1 (0.47) | HSD11B1KDM4EMAPTALDH1A1HSD11B2 | |
| SCHEMBL2824343 | 0.80 | HSD11B1 (0.63) | HSD11B1HSD11B2 | |
| SCHEMBL2827493 | 0.79 | HSD11B1 (0.51) | HSD11B1HSD11B2 | |
| SCHEMBL2833023 | 0.77 | HSD11B1 (0.50) | HSD11B1HSD11B2 | |
| SCHEMBL2825241 | 0.77 | HSD11B1 (0.50) | HSD11B1HSD11B2 | |
| SCHEMBL2824723 | 0.77 | HSD11B1 (0.50) | HSD11B1HSD11B2 | |
| SCHEMBL2833830 | 0.76 | HSD11B1 (0.51) | HSD11B1HSD11B2 | |
| SCHEMBL2827026 | 0.76 | HSD11B1 (0.70) | HSD11B1KDM4EABL1LMNAPOLB | |
| SCHEMBL2827031 | 0.76 | HSD11B1 (0.57) | HSD11B1KDM4EABL1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2243479-A2 | Novel amide and amidine derivates and uses thereof | Abbott Laboratories (US) | 2010-10-27 | — | — | EP | claimed |