Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 19/20 | 0.57 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2828305 | 1.00 | HSD11B1 (0.57) | HSD11B1HSD11B2ALDH1A1MAPT | |
| SCHEMBL2827241 | 0.88 | HSD11B1 (0.57) | HSD11B1HSD11B2ALDH1A1MAPT | |
| SCHEMBL2824524 | 0.87 | HSD11B1 (0.56) | HSD11B1HSD11B2ALDH1A1MAPT | |
| SCHEMBL3951382 | 0.87 | HSD11B1 (0.74) | HSD11B1HSD11B2ALDH1A1MAPT | |
| SCHEMBL2830783 | 0.86 | HSD11B1 (0.77) | HSD11B1HSD11B2 | |
| SCHEMBL2830784 | 0.86 | HSD11B1 (0.77) | HSD11B1HSD11B2 | |
| SCHEMBL2826451 | 0.85 | HSD11B1 (0.62) | HSD11B1HSD11B2 | |
| SCHEMBL2826450 | 0.85 | HSD11B1 (0.62) | HSD11B1HSD11B2 | |
| SCHEMBL2822265 | 0.84 | HSD11B1 (0.79) | HSD11B1HSD11B2 | |
| SCHEMBL2822270 | 0.84 | HSD11B1 (0.79) | HSD11B1HSD11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2243479-A2 | Novel amide and amidine derivates and uses thereof | Abbott Laboratories (US) | 2010-10-27 | — | — | EP | claimed |
| WO-2010123838-A2 | NOVEL AMIDE AND AMIDINE DERIVATIVES AND USES THEREOF | ABBOTT LABORATORIES (US) | 2010-10-28 | — | — | WO | disclosed |