Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 10/20 | 0.43 |
| ▸ | KDM6B | O15054 | 6/20 | 0.40 |
| ▸ | CD38 | P28907 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KDM4A | O75164 | 1/20 | 0.37 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15639467 | 0.85 | SIRT3 (0.46) | SIRT3TDP1KDM4CKDM6BCD38 | |
| SCHEMBL28283057 | 0.80 | TP53 (0.43) | KDM4CKDM6BKDM4EALDH1A1MAPT | |
| SCHEMBL2122995 | 0.77 | MKNK1 (0.57) | SIRT3TDP1KDM4CKDM6BIRAK4 | |
| SCHEMBL3723389 | 0.77 | SIRT3 (0.47) | SIRT3TDP1KDM4CKDM6BIRAK4 | |
| SCHEMBL3716882 | 0.76 | KDM4C (0.67) | SIRT3TDP1KDM4CKDM6BRPS6KB1 | |
| SCHEMBL28284470 | 0.75 | SIRT3 (0.49) | SIRT3TDP1KDM4CKDM6BIRAK4 | |
| SCHEMBL22732130 | 0.75 | SIRT3 (0.51) | SIRT3TDP1KDM4CKDM6BIRAK4 | |
| SCHEMBL662028 | 0.74 | SIRT3 (0.58) | SIRT3TDP1KDM4CKDM6BIRAK4 | |
| SCHEMBL6757557 | 0.74 | SIRT3 (0.58) | SIRT3TDP1KDM4CKDM6BIRAK4 | |
| SCHEMBL7012861 | 0.74 | RPS6KB1 (0.55) | SIRT3TDP1KDM4CKDM6BRPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109641906-A | HETEROARYL SUBSTITUTED AMINOPYRIDINE COMPOUNDS | 百时美施贵宝公司 | 2019-04-16 | — | — | CN | claimed |
| CN-106061967-B | The nicotinamide compounds replaced through heteroaryl | 百时美施贵宝公司 | 2019-04-19 | — | — | CN | disclosed |
| CN-109641906-A | HETEROARYL SUBSTITUTED AMINOPYRIDINE COMPOUNDS | 百时美施贵宝公司 | 2019-04-16 | — | — | CN | disclosed |