Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 7/20 | 0.67 |
| ▸ | KDM6B | O15054 | 6/20 | 0.67 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.58 |
| ▸ | AKT1 | P31749 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 2/20 | 0.55 |
| ▸ | KDM4D | Q6B0I6 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | KDM4A | O75164 | 1/20 | 0.51 |
| ▸ | ASPH | Q12797 | 1/20 | 0.50 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.50 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.50 |
| ▸ | CDC7 | O00311 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.48 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27847518 | 0.87 | KDM4C (0.67) | KDM4CKDM6BRPS6KB1AKT1KDM4D | |
| SCHEMBL10839345 | 0.83 | KDM6B (0.55) | KDM4CKDM6BRPS6KB1AKT1PKM | |
| SCHEMBL5387032 | 0.82 | SIRT2 (0.63) | KDM4CKDM6BRPS6KB1AKT1PKM | |
| SCHEMBL6459323 | 0.81 | KDM6B (0.60) | KDM4CKDM6BKDM4EASPHRIOX2 | |
| SCHEMBL3714861 | 0.80 | MAPT (0.64) | KDM4CKDM6BRPS6KB1AKT1KDM4D | |
| SCHEMBL2713876 | 0.77 | RPS6KB1 (0.55) | KDM4CKDM6BRPS6KB1AKT1PKM | |
| SCHEMBL2511447 | 0.77 | KDM4C (0.78) | KDM4CKDM6BKDM4DKDM4EKDM4A | |
| SCHEMBL2122995 | 0.76 | MKNK1 (0.57) | KDM4CKDM6BKDM4DKDM4EKDM4A | |
| SCHEMBL28283271 | 0.76 | SIRT3 (0.44) | KDM4CKDM6BRPS6KB1AKT1KDM4D | |
| SCHEMBL3723389 | 0.76 | SIRT3 (0.47) | KDM4CKDM6BKDM4EMKNK2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010129802-A1 | INHIBITORS OF JAK | PORTOLA PHARMACEUTICALS, INC. (US) | 2010-11-11 | — | — | WO | claimed |