Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 7/20 | 0.49 |
| ▸ | MAPT | P10636 | 7/20 | 0.49 |
| ▸ | TP53 | P04637 | 7/20 | 0.49 |
| ▸ | NPC1 | O15118 | 6/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | XBP1 | P17861 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | MITF | O75030 | 2/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2160086 | 0.84 | MAPT (0.71) | TLR9MAPTTP53NPC1NPSR1 | |
| SCHEMBL18528954 | 0.82 | TP53 (0.46) | TLR9MAPTTP53NPC1NPSR1 | |
| SCHEMBL4224734 | 0.81 | MAPT (0.72) | TLR9MAPTTP53NPC1NPSR1 | |
| SCHEMBL31456656 | 0.81 | TP53 (0.44) | TLR9MAPTTP53NPC1NPSR1 | |
| SCHEMBL31500546 | 0.77 | NPSR1 (0.47) | MAPTNPSR1ALDH1A1MAPK1HSD17B10 | |
| SCHEMBL7452572 | 0.77 | NPSR1 (0.47) | MAPTNPSR1ALDH1A1MAPK1HSD17B10 | |
| SCHEMBL22389946 | 0.76 | NPSR1 (0.45) | NPSR1ALDH1A1MAPK1MEN1KMT2A | |
| SCHEMBL38663560 | 0.76 | NPSR1 (0.45) | NPSR1ALDH1A1MAPK1L3MBTL1SMN1; SMN2 | |
| SCHEMBL28714986 | 0.74 | NPSR1 (0.44) | TLR9MAPTTP53NPC1NPSR1 | |
| SCHEMBL630198 | 0.74 | NPSR1 (0.44) | MAPTNPSR1ALDH1A1MAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116456985-A | Pyrimidine and pyridine derivatives as HPK1 modulators and methods of use thereof | 深圳市原力生命科学有限公司 | 2023-07-18 | — | — | CN | disclosed |
| CN-114222737-A | Small molecule inhibitor of NF-kB induced kinase | 詹森药业有限公司 | 2022-03-22 | — | — | CN | disclosed |
| CN-109661394-A | FGFR4 inhibitor, preparation method and application pharmaceutically | 上海和誉生物医药科技有限公司 | 2019-04-19 | — | — | CN | disclosed |