Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 12/20 | 0.46 |
| ▸ | MAPT | P10636 | 12/20 | 0.46 |
| ▸ | TLR9 | Q9NR96 | 8/20 | 0.46 |
| ▸ | NPC1 | O15118 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | XBP1 | P17861 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.39 |
| ▸ | MITF | O75030 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31456656 | 0.85 | TP53 (0.44) | TP53MAPTTLR9NPC1ALDH1A1 | |
| SCHEMBL27487649 | 0.82 | NPC1 (0.34) | TP53MAPTTLR9NPC1ALDH1A1 | |
| SCHEMBL28283383 | 0.82 | TLR9 (0.49) | TP53MAPTTLR9NPC1ALDH1A1 | |
| SCHEMBL27320745 | 0.79 | MAPT (0.46) | TP53MAPTTLR9NPC1ALDH1A1 | |
| SCHEMBL2475444 | 0.79 | TP53 (0.64) | TP53MAPTTLR9NPC1ALDH1A1 | |
| SCHEMBL2160086 | 0.79 | MAPT (0.71) | TP53MAPTTLR9NPC1ALDH1A1 | |
| SCHEMBL10582722 | 0.76 | TP53 (0.41) | TP53MAPTTLR9NPC1ALDH1A1 | |
| SCHEMBL6861984 | 0.74 | MAPT (0.43) | TP53MAPTTLR9NPC1ALDH1A1 | |
| SCHEMBL630361 | 0.74 | KMT2A (0.36) | MAPTNPC1ALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL9626944 | 0.73 | TP53 (0.42) | TP53MAPTTLR9NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017029498-A1 | 2-SULFONYLPYRIMIDINES | MEDICAL RESEARCH COUNCIL (GB) | 2017-02-23 | — | — | WO | disclosed |
| CN-1047778-C | Pyrimido [5-4-d] pyrimidines, drugs containing these compounds, their use and process for preparing them | THOMAE GMBH DR K (DE) | 1999-12-29 | — | — | CN | disclosed |