Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.44 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.44 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 7/20 | 0.42 |
| ▸ | FNTA | P49354 | 1/20 | 0.41 |
| ▸ | FNTB | P49356 | 1/20 | 0.41 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | TLR4 | O00206 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9502758 | 0.87 | ALDH1A1 (0.48) | GAASIRT2SIRT1SIRT3AR | |
| SCHEMBL28288026 | 0.80 | GAA (0.53) | GAARCE1SIRT2SIRT1SIRT3 | |
| SCHEMBL4175939 | 0.80 | AR (0.66) | GAASIRT2SIRT1SIRT3AR | |
| SCHEMBL28286633 | 0.78 | GAA (0.50) | GAARCE1SIRT2SIRT1SIRT3 | |
| SCHEMBL5073657 | 0.78 | NR4A1 (0.54) | GAAARMAPTALDH1A1 | |
| SCHEMBL16792664 | 0.77 | AR (0.43) | GAARCE1ARPOLBALDH1A1 | |
| SCHEMBL4184859 | 0.77 | AR (0.68) | AR | |
| SCHEMBL1335043 | 0.77 | ALDH1A1 (0.49) | GAAARPOLBLMNAMAPT | |
| SCHEMBL1334294 | 0.77 | ALDH1A1 (0.49) | GAAARPOLBLMNAMAPT | |
| SCHEMBL11481973 | 0.76 | NR4A1 (0.52) | GAAARPOLBMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109651208-B | N-aryl sulfonamide compound, pharmaceutical composition and application thereof | 中国科学院上海药物研究所 | 2022-01-04 | — | — | CN | disclosed |
| CN-109651208-A | N- arylsulfonamides compound, medical composition and its use | 中国科学院上海药物研究所 | 2019-04-19 | — | — | CN | disclosed |