Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.66 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.52 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.50 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.50 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.50 |
| ▸ | CDC25B | P30305 | 1/20 | 0.49 |
| ▸ | PAM | P19021 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid Monobenzyl Ester SCHEMBL827012 | 1.00 | ALDH1A1 (0.66) | ALDH1A1MAPK1L3MBTL1HTTTDP1 | |
| Succinic Acid Monobenzyl Ester SCHEMBL5991386 | 0.98 | ALDH1A1 (0.63) | ALDH1A1MAPK1L3MBTL1HTTTDP1 | |
| SCHEMBL1177836 | 0.94 | ALDH1A1 (0.73) | ALDH1A1MAPK1L3MBTL1HTTTDP1 | |
| Succinic Acid Monobenzyl Ester SCHEMBL2858793 | 0.93 | ALDH1A1 (0.58) | ALDH1A1MAPK1L3MBTL1HTTTDP1 | |
| Succinic Acid Monobenzyl Ester SCHEMBL28617777 | 0.93 | HTT (0.58) | ALDH1A1MAPK1L3MBTL1HTTTDP1 | |
| Succinic Acid SCHEMBL29551144 | 0.91 | ALDH1A1 (0.58) | ALDH1A1MAPK1L3MBTL1HTTTDP1 | |
| SCHEMBL2587051 | 0.89 | ALDH1A1 (0.61) | ALDH1A1MAPK1L3MBTL1HTTTDP1 | |
| SCHEMBL18674 | 0.89 | ALDH1A1 (0.61) | ALDH1A1MAPK1L3MBTL1HTTTDP1 | |
| SCHEMBL1856208 | 0.88 | ALDH1A1 (0.66) | ALDH1A1MAPK1L3MBTL1HTTTDP1 | |
| SCHEMBL8854045 | 0.87 | HTT (0.59) | ALDH1A1MAPK1L3MBTL1HTTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109580821-A | The detection method of impurity succinic acid in a kind of S- benzyl succinic acid | 山东铂源药业有限公司 | 2019-04-05 | — | — | CN | disclosed |