SCHEMBL28291283

SCHEMBL28291283

O=COC(c1ccccc1)N1CC(C(=O)Cl)C1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.35
S1PR5 Q9H228 2/20 0.34
S1PR1 P21453 1/20 0.34
CYP2D6 P10635 3/20 0.33
KMT2A Q03164 2/20 0.33
CNR1 P21554 1/20 0.33
CNR2 P34972 1/20 0.33
LMNA P02545 2/20 0.33
CHRM2 P08172 2/20 0.32
CHRM4 P08173 2/20 0.32
CHRM5 P08912 2/20 0.32
CHRM1 P11229 2/20 0.32
CHRM3 P20309 2/20 0.32
HSD17B10 Q99714 2/20 0.32
CYP2C9 P11712 1/20 0.32
SLC6A9 P48067 1/20 0.32
CYP3A4 P08684 1/20 0.32
CYP1A2 P05177 1/20 0.32
TSHR P16473 1/20 0.32
MAPK1 P28482 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27825272 0.87 CNR1 (0.39) ALDH1A1CYP2D6KMT2ACNR1CNR2
SCHEMBL28017893 0.86 ALDH1A1 (0.39) ALDH1A1CYP2D6KMT2ACNR1CNR2
SCHEMBL28278578 0.86 TDP1 (0.41) ALDH1A1CYP2D6KMT2ACYP1A2
SCHEMBL28825698 0.85 ALDH1A1 (0.36) ALDH1A1S1PR5S1PR1CYP2D6KMT2A
SCHEMBL27930040 0.82 KCNA3 (0.36) ALDH1A1CYP2D6KMT2ALMNACYP2C9
SCHEMBL27839669 0.77 PIK3CD (0.32)
Hydrochloric Acid SCHEMBL4509686 0.75 ALDH1A1 (0.50) ALDH1A1KMT2ACNR1CNR2SLC6A9
SCHEMBL27630863 0.75 ALDH1A1 (0.39) ALDH1A1CYP2D6KMT2ACNR1CNR2
SCHEMBL28866185 0.75 ALDH1A1 (0.39) ALDH1A1CYP2D6CNR1CNR2LMNA
SCHEMBL28762467 0.73 CYP2D6 (0.37) ALDH1A1CYP2D6KMT2ALMNACHRM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109715626-A Heterocyclic compound as FGFR inhibitor 广州诺诚健华医药科技有限公司 2019-05-03 CN disclosed