Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.38 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.38 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.38 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | CASP6 | P55212 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28737445 | 1.00 | EPHX1 (0.47) | EPHX1POLBHPGDMAPTHTT | |
| SCHEMBL27648307 | 0.83 | HPGD (0.53) | EPHX1POLBHPGDMAPTALDH1A1 | |
| SCHEMBL27648310 | 0.83 | HPGD (0.53) | EPHX1POLBHPGDMAPTALDH1A1 | |
| SCHEMBL28737429 | 0.79 | EPHX1 (0.42) | EPHX1POLBHPGDMAPTHTT | |
| SCHEMBL1802727 | 0.78 | EPHX1 (0.55) | EPHX1POLBGNAI3GNAO1GNAI1 | |
| SCHEMBL255421 | 0.77 | EPHX1 (0.59) | EPHX1POLBGNAI3GNAO1GNAI1 | |
| SCHEMBL28895020 | 0.75 | EPHX1 (0.57) | EPHX1POLBGNAI3GNAO1GNAI1 | |
| SCHEMBL9333374 | 0.75 | EPHX1 (0.44) | EPHX1POLBHPGDGNAI3GNAO1 | |
| SCHEMBL11007528 | 0.73 | EPHX1 (0.53) | EPHX1POLBHPGDSMN1; SMN2GNAI3 | |
| SCHEMBL3414046 | 0.73 | EPHX1 (0.53) | EPHX1POLBGNAI3GNAO1GNAI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109563043-B | Substituted pyridines as inhibitors of DNMT1 | 葛兰素史密斯克莱知识产权发展有限公司 | 2022-05-31 | — | — | CN | disclosed |
| CN-113924292-A | Antimicrobial compounds and methods | 库扎环球有限责任公司 | 2022-01-11 | — | — | CN | disclosed |
| CN-109563043-A | SUBSTITUTED PYRIDINES AS INHIBITORS OF DNMT1 | 葛兰素史密斯克莱知识产权发展有限公司 | 2019-04-02 | — | — | CN | disclosed |