SCHEMBL28291457

SCHEMBL28291457

COc1ccc(C#Cc2ccc3ccccc3c2)cc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.61
CYP2A6 P11509 1/20 0.61
APP P05067 2/20 0.55
KCNH2 Q12809 1/20 0.51
L3MBTL1 Q9Y468 3/20 0.49
LMNA P02545 1/20 0.47
HTT P42858 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
ASIC3 Q9UHC3 2/20 0.46
ACACB O00763 1/20 0.44
CYP1A1 P04798 1/20 0.44
CYP1B1 Q16678 1/20 0.44
NPC1 O15118 2/20 0.44
RAB9A P51151 2/20 0.44
CASP3 P42574 1/20 0.44
SENP7 Q9BQF6 1/20 0.44
CA12 O43570 1/20 0.44
CA1 P00915 1/20 0.44
CA2 P00918 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9743076 0.88 APP (0.59) CYP1A2CYP2A6APPKCNH2L3MBTL1
SCHEMBL17086858 0.87 CYP1A2 (0.60) CYP1A2CYP2A6APPKCNH2L3MBTL1
SCHEMBL17086882 0.87 CYP1A2 (0.59) CYP1A2CYP2A6APPKCNH2L3MBTL1
SCHEMBL5573799 0.83 ASIC3 (0.53) CYP1A2CYP2A6APPTDP1ASIC3
SCHEMBL2233702 0.83 APP (0.53) APPKCNH2CYP1A1CYP1B1NQO1
SCHEMBL9742321 0.83 APP (0.53) CYP1A2CYP2A6APPKCNH2SMN1; SMN2
SCHEMBL8961303 0.82 NPC1 (0.43) CYP1A2CYP2A6APPL3MBTL1LMNA
SCHEMBL9128248 0.82 NPC1 (0.43) CYP1A2CYP2A6APPL3MBTL1LMNA
SCHEMBL12348396 0.81 APP (0.72) APPKCNH2L3MBTL1SMN1; SMN2TDP1
SCHEMBL15014329 0.81 APP (0.72) APPKCNH2SMN1; SMN2ACACBNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109734548-A A kind of preparation method of the aryl alkynes of palladium chtalyst 绍兴文理学院 2019-05-10 CN disclosed