Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 15/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | PRF1 | P14222 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | TYMS | P04818 | 1/20 | 0.38 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.38 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.38 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | NEK2 | P51955 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20574331 | 0.83 | KCNJ1 (0.59) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL30445354 | 0.83 | KCNJ1 (0.59) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL20168056 | 0.82 | KCNJ1 (0.54) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL30751853 | 0.82 | KCNJ1 (0.54) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL286348 | 0.81 | KCNJ1 (0.50) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL29728674 | 0.77 | ESR1 (0.64) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL5449123 | 0.77 | ALDH1A1 (0.44) | KCNJ1PRF1TYMS | |
| SCHEMBL286648 | 0.77 | ESR1 (0.64) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL15036782 | 0.77 | KCNJ1 (0.64) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL30751813 | 0.76 | KCNJ1 (0.58) | KCNJ1KCNH2ACHESSTR1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106432214-B | A method of preparing ROMK channel inhibitor intermediate | 成都拿盛科技有限公司 | 2019-05-07 | — | — | CN | disclosed |