Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 13/20 | 0.47 |
| ▸ | MEN1 | O00255 | 8/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.47 |
| ▸ | RAB9A | P51151 | 5/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GBA1 | P04062 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.39 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.39 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28292454 | 1.00 | MAPT (0.47) | MAPTMEN1KMT2ATDP1RAB9A | |
| SCHEMBL17595329 | 0.78 | MAPT (0.54) | MAPTMEN1KMT2ATDP1RAB9A | |
| SCHEMBL17595330 | 0.78 | MAPT (0.54) | MAPTMEN1KMT2ATDP1RAB9A | |
| SCHEMBL3282369 | 0.76 | LMNA (0.57) | MAPTMEN1KMT2ATDP1RAB9A | |
| SCHEMBL3282366 | 0.76 | LMNA (0.57) | MAPTMEN1KMT2ATDP1RAB9A | |
| SCHEMBL17595117 | 0.76 | MAPT (0.51) | MAPTMEN1KMT2ATDP1RAB9A | |
| SCHEMBL17595119 | 0.76 | MAPT (0.51) | MAPTMEN1KMT2ATDP1RAB9A | |
| SCHEMBL10867692 | 0.75 | MAPT (0.74) | MAPTMEN1KMT2ATDP1RAB9A | |
| SCHEMBL11037604 | 0.75 | MAPT (0.74) | MAPTMEN1KMT2ATDP1RAB9A | |
| SCHEMBL666267 | 0.73 | MEN1 (0.69) | MAPTMEN1KMT2ATDP1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109689661-A | Macrocyclic inhibitors of myeloperoxidase | 百时美施贵宝公司 | 2019-04-26 | — | — | CN | disclosed |