SCHEMBL28292522

SCHEMBL28292522

N#Cc1ccc(-c2ccc3nc[nH]c3c2)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
QPCT Q16769 8/20 0.53
QPCTL Q9NXS2 4/20 0.53
MAP4K4 O95819 1/20 0.48
PRKCI P41743 2/20 0.47
KDM4E B2RXH2 2/20 0.46
MAPT P10636 1/20 0.46
RAD52 P43351 1/20 0.46
ADORA2A P29274 1/20 0.46
BRD4 O60885 1/20 0.46
CREBBP Q92793 1/20 0.46
SCN10A Q9Y5Y9 1/20 0.45
NPC1 O15118 1/20 0.44
ALDH1A1 P00352 1/20 0.44
TP53 P04637 1/20 0.44
HPGD P15428 1/20 0.44
RAB9A P51151 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
RIPK1 Q13546 1/20 0.44
MMP12 P39900 1/20 0.44
PSMD11 O00231 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28292521 0.87 MAP4K4 (0.44) QPCTQPCTLMAP4K4KDM4EMAPT
SCHEMBL29424823 0.86 PRKCI (0.53) PRKCIKDM4EMAPTRAD52ADORA2A
SCHEMBL11134 0.86 PRKCI (0.53) PRKCIKDM4EMAPTRAD52ADORA2A
Hydrochloric Acid SCHEMBL3671411 0.84 KDM4E (0.55) PRKCIKDM4EMAPTRAD52ADORA2A
SCHEMBL8634290 0.84 QPCT (0.68) QPCTQPCTLPRKCIKDM4EMAPT
SCHEMBL2462345 0.79 QPCT (0.68) QPCTQPCTLPRKCIKDM4EMAPT
SCHEMBL38665709 0.77 QPCT (0.66) QPCTQPCTLPRKCIKDM4EMAPT
SCHEMBL28178022 0.77 QPCT (0.61) QPCTQPCTLPRKCIKDM4EMAPT
SCHEMBL7021141 0.77 QPCT (0.66) QPCTQPCTLPRKCIKDM4EMAPT
SCHEMBL28178020 0.77 PSMD11 (0.64) QPCTQPCTLPRKCIKDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106866543-B A method of benzimidazole compound is catalyzed and synthesized under microwave radiation in water phase 福建医科大学 2019-05-14 CN disclosed