Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.55 |
| ▸ | P4HTM | Q9NXG6 | 9/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | VNN1 | O95497 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1685926 | 0.84 | NAMPT (0.54) | NAMPTP4HTMKMT2AKITFLT3 | |
| SCHEMBL23488444 | 0.82 | P4HTM (0.77) | NAMPTP4HTMKMT2ANPC1ALDH1A1 | |
| SCHEMBL17729302 | 0.81 | P4HTM (0.54) | P4HTMKMT2AHDAC3HDAC1HDAC8 | |
| SCHEMBL4251561 | 0.81 | NAMPT (0.50) | NAMPTP4HTMKMT2AKITFLT3 | |
| SCHEMBL13002904 | 0.79 | KIT (0.53) | NAMPTP4HTMKMT2AKITFLT3 | |
| SCHEMBL22227949 | 0.79 | P4HTM (0.55) | P4HTMKMT2AHDAC3HDAC1HDAC8 | |
| SCHEMBL13506191 | 0.78 | ALDH1A1 (0.54) | NAMPTP4HTMKMT2AALDH1A1KDM4E | |
| SCHEMBL28294216 | 0.77 | P4HTM (0.50) | P4HTMHDAC3HDAC1HDAC8HDAC4 | |
| SCHEMBL16423725 | 0.77 | NAMPT (0.39) | NAMPTP4HTMKMT2AHDAC3HDAC1 | |
| SCHEMBL17729266 | 0.77 | P4HTM (0.47) | NAMPTP4HTMHDAC3HDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109689647-B | Bicyclic heteroaryl substituted compounds | 百时美施贵宝公司 | 2023-01-20 | — | — | CN | claimed |
| CN-109689647-B | Bicyclic heteroaryl substituted compounds | 百时美施贵宝公司 | 2023-01-20 | — | — | CN | disclosed |
| CN-109689647-A | The compound that bicyclic heteroaryl replaces | 百时美施贵宝公司 | 2019-04-26 | — | — | CN | disclosed |