M-Xylene

M-Xylene

SCHEMBL28292894

Cc1cccc(C)c1.O=CO

nearest known ligand 0.67

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 5/20 0.67
PARP1 P09874 1/20 0.48
TP53 P04637 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
ALDH1A1 P00352 1/20 0.46
MAPK1 P28482 1/20 0.46
LMNA P02545 1/20 0.45
HDAC8 Q9BY41 1/20 0.45
HDAC6 Q9UBN7 1/20 0.45
HSD17B10 Q99714 1/20 0.45
NPC1 O15118 1/20 0.44
CASP3 P42574 1/20 0.44
SENP8 Q96LD8 1/20 0.44
SENP7 Q9BQF6 1/20 0.44
SENP6 Q9GZR1 1/20 0.44
GAA P10253 1/20 0.43
TSHR P16473 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.42
ALOX5 P09917 1/20 0.42
PTGS1 P23219 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
M-Xylene SCHEMBL28075710 0.97 ACHE (0.63) ACHEPARP1TP53TDP1ALDH1A1
Formic Acid SCHEMBL28188243 0.89 ACHE (0.52) ACHEPARP1TDP1ALDH1A1LMNA
M-Xylene SCHEMBL28804955 0.86 ACHE (0.71) ACHEPARP1TP53TDP1ALDH1A1
Metacresol SCHEMBL28085167 0.85 ACHE (0.77) ACHEPARP1TP53TDP1ALDH1A1
M-Xylene SCHEMBL25222375 0.83 ACHE (0.67) ACHEPARP1TP53TDP1ALDH1A1
M-Xylene SCHEMBL28012478 0.83 ACHE (0.67) ACHEPARP1TP53TDP1ALDH1A1
M-Xylene SCHEMBL27973955 0.83 ACHE (0.67) ACHEPARP1TP53TDP1ALDH1A1
M-Xylene SCHEMBL29220642 0.82 ACHE (0.57) ACHEPARP1TP53TDP1ALDH1A1
M-Xylene SCHEMBL10427453 0.82 ACHE (0.86) ACHEPARP1TP53TDP1ALDH1A1
M-Xylene SCHEMBL11786968 0.82 ACHE (0.86) ACHEPARP1TP53TDP1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109851492-A The synthetic method of 3,5- dimethyl benzoyl chlorides 山东凯盛新材料股份有限公司 2019-06-07 CN disclosed