Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.48 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.47 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.47 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | L3MBTL3 | Q96JM7 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | TRPV6 | Q9H1D0 | 3/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2723246 | 0.90 | MAPT (0.74) | MAPTPOLBCHRNB2CHRNA4CHRNB4 | |
| Piperazine SCHEMBL28139621 | 0.84 | MAPT (0.66) | MAPTPOLBCHRNB2CHRNA4CHRNB4 | |
| SCHEMBL28139531 | 0.82 | L3MBTL3 (0.63) | CHRM4CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL29437410 | 0.80 | MAPT (1.00) | MAPTPOLBCHRNB2CHRNA4CHRNB4 | |
| SCHEMBL2722856 | 0.80 | MAPT (1.00) | MAPTPOLBCHRNB2CHRNA4CHRNB4 | |
| SCHEMBL29684081 | 0.79 | MAPT (0.67) | MAPTPOLBCHRNB2CHRNA4CHRNB4 | |
| SCHEMBL15141576 | 0.79 | MAPT (0.97) | MAPTPOLBCHRNB2CHRNA4CHRNB4 | |
| SCHEMBL29435521 | 0.79 | MAPT (0.97) | MAPTPOLBCHRNB2CHRNA4CHRNB4 | |
| SCHEMBL29649854 | 0.78 | MAPT (0.59) | MAPTPOLBCHRNB2CHRNA4CHRNB4 | |
| SCHEMBL2724789 | 0.78 | POLB (0.76) | MAPTPOLBCHRNB2CHRNA4CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109789143-A | Antiproliferative based on pyrimidine | G1治疗公司 | 2019-05-21 | — | — | CN | disclosed |