Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | POLQ | O75417 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21273616 | 0.90 | ALDH1A1 (0.44) | KDM4EALDH1A1KMT2AMAPK1L3MBTL1 | |
| SCHEMBL1341382 | 0.81 | SMN1; SMN2 (0.39) | KDM4EALDH1A1KMT2AMAPK1L3MBTL1 | |
| SCHEMBL24815466 | 0.79 | MAPT (0.38) | KDM4EALDH1A1MAPK1L3MBTL1SMN1; SMN2 | |
| SCHEMBL10767045 | 0.78 | KDM4E (0.50) | KDM4EALDH1A1KMT2AMAPK1L3MBTL1 | |
| SCHEMBL3560430 | 0.77 | KDM4E (0.46) | KDM4EALDH1A1KMT2AMAPK1L3MBTL1 | |
| SCHEMBL31159368 | 0.76 | ALDH1A1 (0.36) | KDM4EALDH1A1KMT2AMAPK1SMN1; SMN2 | |
| SCHEMBL23088450 | 0.75 | ALDH1A1 (0.44) | KDM4EALDH1A1KMT2AMAPK1SMN1; SMN2 | |
| SCHEMBL29784427 | 0.75 | MAPT (0.38) | KDM4EALDH1A1MAPK1L3MBTL1SMN1; SMN2 | |
| SCHEMBL22574359 | 0.75 | KDM4E (0.38) | KDM4EALDH1A1KMT2AMAPK1SMN1; SMN2 | |
| SCHEMBL27185691 | 0.75 | MAPT (0.38) | KDM4EALDH1A1MAPK1L3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109641890-B | Isocitrate Dehydrogenase (IDH) inhibitors | 浙江迈同生物医药有限公司 | 2022-04-26 | — | — | CN | disclosed |
| CN-109641890-A | Isocitric dehydrogenase (IDH) inhibitor | 上海迈同生物科技有限公司 | 2019-04-16 | — | — | CN | disclosed |