Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNMA1 | Q12791 | 12/20 | 0.68 |
| ▸ | POLB | P06746 | 1/20 | 0.68 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.65 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.61 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.61 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.61 |
| ▸ | CA12 | O43570 | 1/20 | 0.58 |
| ▸ | CA1 | P00915 | 1/20 | 0.58 |
| ▸ | CA2 | P00918 | 1/20 | 0.58 |
| ▸ | CA9 | Q16790 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1883373 | 0.91 | CA12 (0.71) | KCNMA1POLBCHRNA7NTRK1CDK19 | |
| SCHEMBL1882786 | 0.89 | NTRK1 (0.60) | KCNMA1POLBCHRNA7NTRK1CDK19 | |
| SCHEMBL7254163 | 0.89 | KCNMA1 (0.60) | KCNMA1POLBCHRNA7NTRK1CDK19 | |
| SCHEMBL1883575 | 0.88 | GRIK1 (0.70) | KCNMA1POLBNTRK1CDK19GRIK1 | |
| SCHEMBL9170975 | 0.86 | POLB (0.71) | KCNMA1POLBCHRNA7GRIK1CA1 | |
| SCHEMBL4358434 | 0.85 | KCNMA1 (0.68) | KCNMA1POLBCHRNA7NTRK1CDK19 | |
| SCHEMBL1885192 | 0.85 | MEN1 (0.71) | POLBCHRNA7NTRK1CDK19CA12 | |
| SCHEMBL9792728 | 0.85 | KCNMA1 (0.60) | KCNMA1POLBCHRNA7NTRK1CDK19 | |
| SCHEMBL7256022 | 0.84 | KCNMA1 (0.55) | KCNMA1POLBCHRNA7NTRK1CDK19 | |
| SCHEMBL4357763 | 0.84 | KCNMA1 (0.55) | KCNMA1POLBCHRNA7NTRK1CDK19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109704982-B | Preparation method of eltrombopag intermediate 2-hydroxy-3- (m-carboxyphenyl) aniline | 上海天慈国际药业有限公司 | 2021-09-07 | — | — | CN | disclosed |
| CN-109704982-A | A kind of preparation method of eltrombopag olamine intermediate 2- hydroxyl -3- (carboxyl phenyl) aniline | 上海天慈国际药业有限公司 | 2019-05-03 | — | — | CN | disclosed |