Acetic Acid

Acetic Acid

SCHEMBL28296174

CC(=O)[O-].COc1ccc(CN)cc1.[K+]

nearest known ligand 0.56

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Known targets — ChEMBL curated mechanism

ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 3/20 0.56
LOXL2 Q9Y4K0 1/20 0.50
TAAR1 Q96RJ0 1/20 0.50
SMN1; SMN2 Q16637 2/20 0.49
HTT P42858 1/20 0.49
LDHA P00338 1/20 0.49
CA1 P00915 3/20 0.48
CA2 P00918 3/20 0.48
KLKB1 P03952 1/20 0.48
F2RL1 P55085 1/20 0.47
KDM4E B2RXH2 1/20 0.47
SLC6A4 P31645 1/20 0.47
IDO1 P14902 1/20 0.46
AGXT P21549 1/20 0.46
PARP1 P09874 1/20 0.46
PARP10 Q53GL7 1/20 0.46
PARP2 Q9UGN5 1/20 0.46
PARP4 Q9UKK3 1/20 0.46
ALDH1A1 P00352 1/20 0.45
CYP3A4 P08684 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acetic Acid SCHEMBL28065462 0.89 MAOB (0.59) MAOBLOXL2TAAR1SMN1; SMN2HTT
Bicarbonate SCHEMBL25353301 0.86 MAOB (0.61) MAOBLOXL2TAAR1SMN1; SMN2HTT
Methyl Alcohol SCHEMBL28283803 0.84 MAOB (0.68) MAOBLOXL2TAAR1CA1CA2
SCHEMBL4951818 0.84 MAOB (0.73) MAOBTAAR1SMN1; SMN2CA1CA2
SCHEMBL8755 0.84 MAOB (0.73) MAOBTAAR1SMN1; SMN2CA1CA2
Hypochlorous Acid SCHEMBL10950049 0.82 MAOB (0.66) MAOBLOXL2TAAR1CA1CA2
Iodide SCHEMBL28780684 0.82 MAOB (0.70) MAOBTAAR1SMN1; SMN2CA1CA2
Hydrochloric Acid SCHEMBL1715149 0.82 MAOB (0.77) MAOBTAAR1CA1CA2SLC6A4
Ammonia Solution, Strong SCHEMBL9173570 0.82 MAOB (0.70) MAOBTAAR1SMN1; SMN2CA1CA2
Bromide SCHEMBL31513712 0.82 MAOB (0.70) MAOBTAAR1SMN1; SMN2CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109689641-A A kind of substituted 2- hydrogen-pyrazole derivatives crystal form, salt form and preparation method thereof 正大天晴药业集团股份有限公司 2019-04-26 CN disclosed