SCHEMBL28296851

SCHEMBL28296851

NC=S.c1ccc([C@H]2CCNC2)cc1

nearest known ligand 0.81

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
SLC18A3 Q16572 2/20 0.62
SIGMAR1 Q99720 1/20 0.62
HTR3A P46098 1/20 0.55
JAK3 P52333 2/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28298504 1.00 SLC18A3 (0.62) SLC18A3SIGMAR1HTR3AJAK3
SCHEMBL28298515 1.00 SLC18A3 (0.62) SLC18A3SIGMAR1HTR3AJAK3
SCHEMBL28296875 0.91 DRD2 (0.51) SLC18A3SIGMAR1HTR3AJAK3
SCHEMBL495695 0.90 SLC18A3 (0.75) SLC18A3SIGMAR1HTR3AJAK3
SCHEMBL495697 0.90 SLC18A3 (0.75) SLC18A3SIGMAR1HTR3AJAK3
SCHEMBL4122 0.90 SLC18A3 (0.75) SLC18A3SIGMAR1HTR3AJAK3
Hydrochloric Acid SCHEMBL4573453 0.88 SLC18A3 (0.72) SLC18A3SIGMAR1HTR3AJAK3
Hydrochloric Acid SCHEMBL2173028 0.88 SLC18A3 (0.72) SLC18A3SIGMAR1HTR3AJAK3
Hydrochloric Acid SCHEMBL30098419 0.88 SLC18A3 (0.72) SLC18A3SIGMAR1HTR3AJAK3
Hydrochloric Acid SCHEMBL2175594 0.88 SLC18A3 (0.72) SLC18A3SIGMAR1HTR3AJAK3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109715155-A blood brain barrier-penetrating agent dopamine- β -hydroxylase inhibitors 巴尔-波特拉及康邦亚股份有限公司 2019-05-03 CN disclosed