Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Cystamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.69 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.69 |
| ▸ | TSHR | P16473 | 4/20 | 0.62 |
| ▸ | THPO | P40225 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
| ▸ | DNM1 | Q05193 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cystamine SCHEMBL28010098 | 0.87 | MAPT (0.79) | MAPTTDP1EHMT2TSHRTHPO | |
| Cystamine SCHEMBL27861318 | 0.87 | MAPT (0.79) | MAPTTDP1EHMT2TSHRTHPO | |
| Cystamine SCHEMBL27901365 | 0.83 | TSHR (0.77) | MAPTTDP1EHMT2TSHRTHPO | |
| Cystamine SCHEMBL196510 | 0.83 | — | — | |
| Cystamine SCHEMBL345893 | 0.83 | MAPT (1.00) | MAPTTDP1EHMT2TSHRTHPO | |
| Cystamine SCHEMBL320311 | 0.83 | MAPT (1.00) | MAPTTDP1EHMT2TSHRTHPO | |
| Cystamine SCHEMBL28842776 | 0.83 | MAPT (1.00) | MAPTTDP1EHMT2TSHRTHPO | |
| Cystamine SCHEMBL28235943 | 0.83 | MAPT (1.00) | MAPTTDP1EHMT2TSHRTHPO | |
| Cystamine SCHEMBL28418529 | 0.79 | MAPT (0.92) | MAPTTDP1EHMT2TSHRTHPO | |
| Cystamine SCHEMBL28409923 | 0.79 | MAPT (0.92) | MAPTTDP1EHMT2TSHRTHPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109705359-A | A kind of poly- decanedioic acid of modified poly (ethylene glycol)-(PEGS) injectable bioelastomer and its preparation method and application | 华东理工大学 | 2019-05-03 | — | — | CN | disclosed |