Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | ALPI | P09923 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.55 |
| ▸ | XIAP | P98170 | 1/20 | 0.55 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.55 |
| ▸ | IDO1 | P14902 | 1/20 | 0.51 |
| ▸ | BHMT | Q93088 | 4/20 | 0.50 |
| ▸ | BHMT2 | Q9H2M3 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | KIF11 | P52732 | 3/20 | 0.47 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.47 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.47 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.47 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2829688 | 1.00 | CYP2C19 (0.61) | CYP2C19ALPIPKMPTGS1XIAP | |
| SCHEMBL341585 | 1.00 | CYP2C19 (0.61) | CYP2C19ALPIPKMPTGS1XIAP | |
| Benzenemethanethiol SCHEMBL11583114 | 0.92 | CYP2C19 (0.53) | CYP2C19ALPIPKMPTGS1XIAP | |
| SCHEMBL2453778 | 0.90 | CYP2C19 (0.57) | CYP2C19ALPIPKMPTGS1XIAP | |
| SCHEMBL2452642 | 0.89 | CYP2C19 (0.56) | CYP2C19ALPIPKMPTGS1XIAP | |
| SCHEMBL31425189 | 0.87 | FOLH1 (0.51) | CYP2C19BHMTBHMT2KIF11 | |
| SCHEMBL6051732 | 0.85 | LMNA (0.49) | PKMBHMTBHMT2ALDH1A1LMNA | |
| SCHEMBL19800812 | 0.85 | LMNA (0.49) | PKMBHMTBHMT2ALDH1A1LMNA | |
| SCHEMBL31060471 | 0.85 | HPGD (0.49) | CYP2C19BHMTBHMT2ALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL29199143 | 0.85 | ALPI (0.53) | CYP2C19ALPIPKMPTGS1XIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9718921-B2 | Amphiphilic derivatives of thioether containing block copolypeptides | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-08-01 | — | — | US | claimed |
| US-20160002405-A1 | AMPHIPHILIC DERIVATIVES OF THIOETHER CONTAINING BLOCK COPOLYPEPTIDES | NATIONAL SCIENCE FOUNDATION | 2016-01-07 | — | — | US | claimed |
| EP-2961758-A1 | AMPHIPHILIC DERIVATIVES OF THIOETHER CONTAINING BLOCK COPOLYPEPTIDES | The Regents of The University of California (US) | 2016-01-06 | — | — | EP | claimed |
| US-20150057433-A1 | PREPARATION OF FUNCTIONALIZED POLYPEPTIDES, PEPTIDES, AND PROTEINS BY ALKYLATION OF THIOETHER GROUPS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2015-02-26 | — | — | US | claimed |
| EP-2831090-A1 | PREPARATION OF FUNCTIONALIZED POLYPEPTIDES, PEPTIDES, AND PROTEINS BY ALKYLATION OF THIOETHER GROUPS | The Regents of The University of California (US) | 2015-02-04 | — | — | EP | claimed |
| WO-2014134203-A9 | AMPHIPHILIC DERIVATIVES OF THIOETHER CONTAINING BLOCK COPOLYPEPTIDES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-10-23 | — | — | WO | claimed |
| WO-2014134203-A1 | AMPHIPHILIC DERIVATIVES OF THIOETHER CONTAINING BLOCK COPOLYPEPTIDES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-09-04 | — | — | WO | claimed |
| WO-2013148727-A1 | PREPARATION OF FUNCTIONALIZED POLYPEPTIDES, PEPTIDES, AND PROTEINS BY ALKYLATION OF THIOETHER GROUPS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-10-03 | — | — | WO | claimed |
| EP-1874790-B1 | NEW S-ADENOSYL-L-METHIONINE ANALOGS WITH EXTENDED ACTIVATED GROUPS FOR TRANSFER BY METHYLTRANSFERASES | RWTH AACHEN (DE) | 2010-08-18 | — | — | EP | disclosed |
| EP-1712557-A1 | New s-adenosyl-L-methionine analogues with extended activated groups for transfer by methyltransferases | RWTH Aachen (DE) | 2006-10-18 | — | — | EP | disclosed |
| EP-1123919-A1 | PROCESS FOR PRODUCING PEPTIDYL ALDEHYDES | Senju Pharmaceutical Co., Ltd. (JP) | 2001-08-16 | — | — | EP | disclosed |
| US-4477441-A | HYPOTENSIVE AGENTS | MERCK & CO., INC. (US) | 1984-10-16 | — | — | US | disclosed |
| US-4477440-A | HYPERTENSIVE AGENTS; HYPERALDOSTERONISM; MEDICAL DIAGNOSIS; CYCLIC POLYPEPTIDES | MERCK & CO., INC. (US) | 1984-10-16 | — | — | US | disclosed |
| EP-0048159-A2 | Novel carboxyalkyl peptides and thioethers and ethers of peptides as antihypertensive agents | UNIVERSITY OF MIAMI (US) | 1982-03-24 | — | — | EP | disclosed |
| US-4153729-A | ANTILIPEMIC AGENTS | RECHERCHES PHARMACEUTIQUES ET SCIENTIFIQUES (FR) | 1979-05-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150057433-A1 | PREPARATION OF FUNCTIONALIZED POLYPEPTIDES, PEPTIDES, AND PROTEINS BY ALKYLATION OF THIOETHER GROUPS | PTMS, TMT1A, PTMA | CYP2C19 2994/4885ALPI 4202/4885PKM 3705/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.