Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDYL2 | Q8N8U2 | 5/20 | 0.80 |
| ▸ | CDYL | Q9Y232 | 5/20 | 0.80 |
| ▸ | CBX7 | O95931 | 4/20 | 0.80 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 3/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.77 |
| ▸ | POLB | P06746 | 2/20 | 0.63 |
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.61 |
| ▸ | USP2 | O75604 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4379269 | 0.91 | ALDH1A1 (0.73) | CDYL2CDYLCBX7CDY1; CDY1BALDH1A1 | |
| SCHEMBL4386342 | 0.90 | ALDH1A1 (0.75) | CDYL2CDYLCBX7CDY1; CDY1BALDH1A1 | |
| SCHEMBL4385817 | 0.82 | ALDH1A1 (0.63) | CDYL2CDYLCBX7CDY1; CDY1BALDH1A1 | |
| SCHEMBL13779939 | 0.81 | ALDH1A1 (0.79) | ALDH1A1POLBTSHRL3MBTL1USP2 | |
| SCHEMBL4381097 | 0.76 | ALDH1A1 (0.69) | ALDH1A1POLBTSHRL3MBTL1USP2 | |
| SCHEMBL4386911 | 0.75 | TSHR (0.70) | ALDH1A1POLBTSHRL3MBTL1USP2 | |
| SCHEMBL12124515 | 0.74 | — | — | |
| Hydrochloric Acid SCHEMBL4380692 | 0.74 | TSHR (0.69) | ALDH1A1POLBTSHRL3MBTL1USP2 | |
| SCHEMBL12124510 | 0.73 | — | — | |
| SCHEMBL12124405 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | claimed |
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | disclosed |
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | disclosed |
| US-7064135-B2 | Substituted piperidines | NOVO NORDISK INC. (DK) | 2006-06-20 | — | — | US | disclosed |