Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 9/20 | 0.67 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.67 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.67 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.67 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.41 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27546673 | 0.80 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL6250930 | 0.80 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL858101 | 0.74 | MAPK14 (0.63) | MAPK14MAPK13MAPK12MAPK11MAPT | |
| SCHEMBL7921814 | 0.72 | ADORA2A (0.76) | MAPK14MAPK13MAPK12MAPK11GSK3B | |
| SCHEMBL25029271 | 0.71 | ALDH1A1 (0.54) | MAPK14MAPK13MAPK12MAPK11MAPT | |
| SCHEMBL1780573 | 0.70 | MAPK13 (0.59) | MAPK14MAPK13MAPK12MAPK11GSK3B | |
| SCHEMBL1777550 | 0.70 | MAPK13 (0.48) | MAPK14MAPK13MAPK12MAPK11MAPT | |
| SCHEMBL10395104 | 0.70 | CDC7 (0.70) | GSK3BCDK5CDK5R1CDC7ROCK2 | |
| SCHEMBL6525744 | 0.70 | AURKA (0.60) | MAPK14MAPK13MAPK12MAPK11MAPT | |
| SCHEMBL6246075 | 0.69 | MAPK14 (0.66) | MAPK14MAPK13MAPK12MAPK11MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106854205-B | Inhibitors of influenza virus replication and methods of use and uses thereof | 广东东阳光药业有限公司 | 2019-07-09 | — | — | CN | disclosed |
| CN-109748915-A | Inhibitors of influenza viruses replication and its application method and purposes | 广东东阳光药业有限公司 | 2019-05-14 | — | — | CN | disclosed |