Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Pyrimidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F7 | P08709 | 1/20 | 0.35 |
| ▸ | F3 | P13726 | 1/20 | 0.35 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.35 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.35 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.35 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.35 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | NQO2 | P16083 | 7/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyrimidine SCHEMBL28203972 | 0.98 | HCAR2 (0.36) | F7F3SARM1SIRT2SIRT6 | |
| Pyrimidine SCHEMBL1312634 | 0.89 | FFAR3 (0.44) | FFAR3LCKFYNHCAR2ALDH1A1 | |
| Pyrimidine SCHEMBL27578593 | 0.87 | LMNA (0.47) | F7F3SARM1SIRT2SIRT6 | |
| Pyrimidine SCHEMBL15510741 | 0.85 | FFAR3 (0.35) | FFAR3LCKFYNHCAR2ALDH1A1 | |
| Pyrimidine SCHEMBL27677236 | 0.84 | FFAR3 (0.39) | FFAR3LCKFYNLMNAHCAR2 | |
| Pyrimidine SCHEMBL15570711 | 0.84 | FFAR3 (0.39) | FFAR3LCKFYNHCAR2ALDH1A1 | |
| Pyrimidine SCHEMBL15572709 | 0.84 | FFAR3 (0.39) | FFAR3LCKFYNHCAR2ALDH1A1 | |
| Pyrimidine SCHEMBL1150634 | 0.84 | F7 (0.46) | F7F3SARM1SIRT2SIRT6 | |
| Pyrimidine SCHEMBL29415841 | 0.84 | TSHR (0.39) | F7F3SARM1SIRT2SIRT6 | |
| Pyrimidine SCHEMBL28643613 | 0.84 | F7 (0.46) | F7F3SARM1SIRT2SIRT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107641337-B | A kind of amion acetic acid pyrimidine radicals fluorescent whitening agent and its preparation method and application | 贺州学院 | 2019-05-21 | — | — | CN | disclosed |