Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Dipyridyl. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.93 |
| ▸ | LMNA | P02545 | 3/20 | 0.93 |
| ▸ | CCR1 | P32246 | 3/20 | 0.93 |
| ▸ | CCR5 | P51681 | 3/20 | 0.93 |
| ▸ | CCR8 | P51685 | 3/20 | 0.93 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.93 |
| ▸ | POLB | P06746 | 1/20 | 0.93 |
| ▸ | METAP1 | P53582 | 1/20 | 0.93 |
| ▸ | BLM | P54132 | 1/20 | 0.93 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.93 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.93 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.93 |
| ▸ | NPC1 | O15118 | 6/20 | 0.74 |
| ▸ | TP53 | P04637 | 4/20 | 0.74 |
| ▸ | RAB9A | P51151 | 4/20 | 0.74 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.74 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.74 |
| ▸ | HTT | P42858 | 2/20 | 0.74 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dipyridyl SCHEMBL28812305 | 1.00 | KDM4E (0.93) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL11515039 | 1.00 | KDM4E (0.93) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL809478 | 0.97 | KDM4E (0.88) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL5922 | 0.97 | KDM4E (1.00) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL29351528 | 0.97 | KDM4E (1.00) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL29907716 | 0.97 | KDM4E (1.00) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL3711450 | 0.97 | KDM4E (1.00) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL183651 | 0.93 | KDM4E (0.93) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL4577373 | 0.93 | KDM4E (0.93) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL7909040 | 0.93 | KDM4E (0.93) | KDM4ELMNACCR1CCR5CCR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113314750-B | Bipyridine iodonium salt symmetric bipolar active substance and application thereof in salt-cavity battery | 中盐金坛盐化有限责任公司 | 2022-05-27 | — | — | CN | claimed |
| CN-109796396-A | A kind of preparation method of N- methyl -4,4 '-bipyridyl iodide | 山西医科大学 | 2019-05-24 | — | — | CN | claimed |
| CN-113372393-B | Pt complex containing 5-aminofluorescein ligand and preparation method and application thereof | 中国科学院化学研究所 | 2022-09-23 | — | — | CN | disclosed |
| CN-113314750-B | Bipyridine iodonium salt symmetric bipolar active substance and application thereof in salt-cavity battery | 中盐金坛盐化有限责任公司 | 2022-05-27 | — | — | CN | disclosed |
| CN-113314750-B | Bipyridine iodonium salt symmetric bipolar active substance and application thereof in salt-cavity battery | 中盐金坛盐化有限责任公司 | 2022-05-27 | — | — | CN | disclosed |
| CN-113314750-B | Bipyridine iodonium salt symmetric bipolar active substance and application thereof in salt-cavity battery | 中盐金坛盐化有限责任公司 | 2022-05-27 | — | — | CN | disclosed |
| CN-114478397-A | Bipyrimidine iodonium salt, preparation method and application thereof in inverted perovskite solar cell | 苏州大学 | 2022-05-13 | — | — | CN | disclosed |
| CN-113314750-A | Bipyridine iodonium salt symmetric bipolar active substance and application thereof in salt-cavity battery | 中盐金坛盐化有限责任公司 | 2021-08-27 | — | — | CN | disclosed |
| CN-106188147-B | Pt complex containing quinazoline ligand as well as preparation method and application thereof | 中国科学院化学研究所 | 2021-08-20 | — | — | CN | disclosed |