Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | GRN | P28799 | 2/20 | 0.33 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.33 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7054295 | 0.81 | TDP1 (0.41) | TDP1CYP2C9KMT2AMEN1POLB | |
| SCHEMBL1666475 | 0.78 | TDP1 (0.40) | TDP1CYP2C9KMT2AMEN1POLB | |
| SCHEMBL7054292 | 0.75 | AR (0.45) | TDP1CYP2C9KMT2AMEN1POLB | |
| SCHEMBL1529508 | 0.74 | TDP1 (0.45) | TDP1CYP2C9KMT2AMEN1POLB | |
| SCHEMBL2783116 | 0.71 | CYP2C9 (0.54) | TDP1CYP2C9KMT2AMEN1POLB | |
| SCHEMBL3674837 | 0.71 | TDP1 (0.46) | TDP1CYP2C9KMT2AMEN1POLB | |
| SCHEMBL5174989 | 0.71 | TDP1 (0.46) | TDP1CYP2C9KMT2AMEN1POLB | |
| SCHEMBL370476 | 0.69 | TDP1 (0.45) | TDP1CYP2C9KMT2AMEN1POLB | |
| SCHEMBL781811 | 0.69 | TDP1 (0.45) | TDP1CYP2C9KMT2AMEN1POLB | |
| SCHEMBL1277680 | 0.69 | KMT2A (0.53) | TDP1CYP2C9KMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170905-A2 | SIRTUIN MODULATING THIAZOLOPYRIDINE COMPOUNDS | Sirtris Pharmaceuticals, Inc. (US) | 2010-04-07 | — | — | EP | disclosed |
| WO-2008156869-A2 | SIRTUIN MODULATING THIAZOLOPYRIDINE COMPOUNDS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2008-12-24 | — | — | WO | disclosed |