Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 8/20 | 0.71 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2826336 | 0.89 | GRM5 (0.70) | GRM5 | |
| SCHEMBL2832204 | 0.87 | GRM5 (0.56) | GRM5JAK2 | |
| SCHEMBL2832138 | 0.86 | GRM5 (0.56) | GRM5KDM4EJAK2 | |
| SCHEMBL2832964 | 0.86 | GRM5 (0.52) | GRM5NOTUMJAK2 | |
| SCHEMBL2829041 | 0.85 | GRM5 (0.54) | GRM5PIK3CA | |
| SCHEMBL2830193 | 0.85 | GRM5 (0.51) | GRM5JAK2 | |
| SCHEMBL2829440 | 0.85 | GRM5 (0.51) | GRM5 | |
| SCHEMBL2830123 | 0.85 | GRM5 (0.51) | GRM5JAK2 | |
| SCHEMBL2826585 | 0.84 | GRM5 (0.52) | GRM5PIK3CAPIK3CGNAMPTJAK2 | |
| SCHEMBL2829034 | 0.83 | GRM5 (0.71) | GRM5CDK5CDK5R1PIK3CAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |