Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 8/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
| ▸ | NAMPT | P43490 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | SIGLEC9 | Q9Y336 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2828771 | 0.89 | GRM5 (0.55) | GRM5HSD17B10 | |
| SCHEMBL2824785 | 0.86 | GRM5 (0.70) | GRM5JAK2JAK3 | |
| SCHEMBL2826008 | 0.85 | GRM5 (0.57) | GRM5PIK3CGPIK3CAMAPTKDM4E | |
| SCHEMBL2826585 | 0.85 | GRM5 (0.52) | GRM5PIK3CGPIK3CANAMPTMAPT | |
| SCHEMBL2826273 | 0.84 | GRM5 (0.56) | GRM5HSD17B10PIK3CGPIK3CANAMPT | |
| SCHEMBL2827389 | 0.84 | GRM5 (0.51) | GRM5PIK3CGPIK3CANAMPTMAPT | |
| SCHEMBL2830236 | 0.83 | GRM5 (0.71) | GRM5PIK3CGPIK3CANAMPTKDM4E | |
| SCHEMBL2830049 | 0.82 | GRM5 (0.60) | GRM5PIK3CGPIK3CANAMPTMAPT | |
| SCHEMBL2827024 | 0.82 | GRM5 (0.49) | GRM5PIK3CGPIK3CANAMPTMAPT | |
| SCHEMBL2827684 | 0.82 | GRM5 (0.48) | GRM5PIK3CGPIK3CANAMPTJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |