Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 12/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.34 |
| ▸ | JAK2 | O60674 | 4/20 | 0.33 |
| ▸ | KIF11 | P52732 | 2/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28305238 | 0.78 | NTRK1 (0.37) | NTRK1RIPK1JAK2KIF11 | |
| SCHEMBL21313037 | 0.77 | NTRK1 (0.41) | NTRK1JAK2 | |
| SCHEMBL28213704 | 0.73 | KDM1A (0.36) | NTRK1RIPK1JAK2KIF11TRPA1 | |
| SCHEMBL28613334 | 0.72 | TRPA1 (0.45) | NTRK1RIPK1JAK2KIF11TRPA1 | |
| SCHEMBL28613335 | 0.72 | TRPA1 (0.45) | NTRK1RIPK1JAK2KIF11TRPA1 | |
| SCHEMBL22578587 | 0.68 | NTRK1 (0.45) | NTRK1JAK2 | |
| SCHEMBL28297763 | 0.67 | — | — | |
| SCHEMBL28297762 | 0.67 | — | — | |
| SCHEMBL431877 | 0.66 | NR1H2 (0.38) | NTRK1JAK2 | |
| SCHEMBL445674 | 0.66 | NR1H2 (0.38) | NTRK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109890820-A | Amino-pyrazol as neurotrophic factor tyrosine kinase receptor inhibitor and pyrimidine compound | 正大天晴药业集团股份有限公司 | 2019-06-14 | — | — | CN | disclosed |