Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 7/20 | 0.71 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.44 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.44 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | RHOA | P61586 | 1/20 | 0.42 |
| ▸ | IKBKB | O14920 | 1/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2829389 | 0.90 | GRM5 (0.69) | GRM5RAB9ASMN1; SMN2HTTTP53 | |
| SCHEMBL2824929 | 0.85 | CA12 (0.55) | GRM5CA12CA2CA9NPC1 | |
| SCHEMBL2828570 | 0.84 | GRM5 (0.67) | GRM5SORT1 | |
| SCHEMBL2828501 | 0.83 | GRM5 (0.69) | GRM5CA12CA2CA9NPC1 | |
| SCHEMBL2831124 | 0.82 | GRM5 (0.64) | GRM5NPC1RAB9ASORT1MEN1 | |
| SCHEMBL2826306 | 0.80 | GRM5 (0.74) | GRM5NPC1SORT1MEN1KMT2A | |
| SCHEMBL24010655 | 0.80 | NPC1 (0.58) | NPC1RAB9ACSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL2828893 | 0.78 | GRM5 (0.60) | GRM5 | |
| SCHEMBL10593099 | 0.77 | RHOA (0.56) | CA12CA2CA9NPC1RAB9A | |
| SCHEMBL24010908 | 0.76 | BRAF (0.61) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |