Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 11/20 | 0.69 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2824776 | 0.90 | GRM5 (0.67) | GRM5TP53 | |
| SCHEMBL2830779 | 0.83 | GRM5 (0.71) | GRM5CA12CA2CA9TP53 | |
| SCHEMBL2824929 | 0.83 | CA12 (0.55) | GRM5CA12CA2CA9TP53 | |
| SCHEMBL2846654 | 0.82 | GRM5 (1.00) | GRM5 | |
| SCHEMBL10593099 | 0.79 | RHOA (0.56) | CA12CA2CA9TP53NPC1 | |
| SCHEMBL2826666 | 0.76 | ROCK1 (0.46) | GRM5 | |
| SCHEMBL2829389 | 0.73 | GRM5 (0.69) | GRM5TP53RAB9A | |
| SCHEMBL2826005 | 0.73 | GRM5 (0.50) | GRM5TP53NPC1RAB9A | |
| SCHEMBL2828221 | 0.72 | LDHA (0.51) | GRM5TP53RAB9A | |
| SCHEMBL2846652 | 0.72 | GRM5 (0.81) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |