Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.81 |
| ▸ | ATM | Q13315 | 1/20 | 0.81 |
| ▸ | LMNA | P02545 | 3/20 | 0.79 |
| ▸ | TSHR | P16473 | 1/20 | 0.79 |
| ▸ | NPC1 | O15118 | 4/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 5/20 | 0.58 |
| ▸ | USP2 | O75604 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5928664 | 0.91 | SMN1; SMN2 (0.92) | SMN1; SMN2ATMLMNATSHRNPC1 | |
| SCHEMBL28308015 | 0.90 | SMN1; SMN2 (1.00) | SMN1; SMN2ATMLMNATSHRNPC1 | |
| SCHEMBL28307048 | 0.88 | LMNA (1.00) | SMN1; SMN2ATMLMNATSHRNPC1 | |
| SCHEMBL28308021 | 0.88 | LMNA (1.00) | SMN1; SMN2ATMLMNATSHRNPC1 | |
| SCHEMBL3714715 | 0.87 | SMN1; SMN2 (0.71) | SMN1; SMN2ATMLMNATSHRNPC1 | |
| SCHEMBL14743414 | 0.86 | SMN1; SMN2 (0.69) | SMN1; SMN2ATMLMNATSHRNPC1 | |
| SCHEMBL18017411 | 0.83 | HDAC6 (0.71) | SMN1; SMN2ATMLMNATSHRKDM4E | |
| SCHEMBL5928772 | 0.81 | NPC1 (0.64) | SMN1; SMN2ATMLMNATSHRNPC1 | |
| SCHEMBL28677827 | 0.80 | SMN1; SMN2 (0.62) | SMN1; SMN2ATMLMNATSHRNPC1 | |
| SCHEMBL5928915 | 0.80 | NPC1 (0.72) | SMN1; SMN2ATMLMNATSHRNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110041306-B | 4-hydroxy-2-quinolone-N- (4-quinazolinone) -3-carboxamide derivatives | 中国医学科学院药物研究所 | 2022-01-11 | — | — | CN | disclosed |
| CN-110041306-A | 4- hydroxyl -2- quinolone-nitrogen-(4- quinazolinone) -3- carboxamides derivatives | 中国医学科学院药物研究所 | 2019-07-23 | — | — | CN | disclosed |