Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 2/20 | 0.45 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | GSK3A | P49840 | 2/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL692100 | 0.86 | HPGD (0.49) | ATRGSK3BMAPTSIRT3TDP1 | |
| SCHEMBL28313914 | 0.83 | GSK3B (0.43) | ATRGSK3BMAPTSIRT3TDP1 | |
| SCHEMBL555073 | 0.81 | NAMPT (0.48) | ATRGSK3BMAPTSIRT3TDP1 | |
| SCHEMBL2033252 | 0.80 | KDM4C (0.50) | ATRGSK3BMAPTSIRT3TDP1 | |
| SCHEMBL30600744 | 0.80 | KDM4C (0.50) | ATRGSK3BMAPTSIRT3TDP1 | |
| SCHEMBL1637363 | 0.79 | ALDH1A1 (0.55) | ATRGSK3BMAPTSIRT3TDP1 | |
| SCHEMBL30418934 | 0.79 | ALDH1A1 (0.55) | ATRGSK3BMAPTSIRT3TDP1 | |
| SCHEMBL896640 | 0.78 | KMT2A (0.51) | MAPTTDP1GSK3AMEN1LMNA | |
| SCHEMBL25046269 | 0.77 | MAPT (0.46) | ATRGSK3BMAPTSIRT3TDP1 | |
| SCHEMBL27684513 | 0.77 | SIRT3 (0.55) | ATRGSK3BMAPTSIRT3TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106661018-B | Pyrrolo- [2,3-C] pyridine as neurofibrillary tangles imaging agent | 默沙东公司 | 2019-07-19 | — | — | CN | disclosed |
| CN-109923114-A | Pyrazolopyridine derivatives as HPK1 modulators and their use for the treatment of cancer | 因赛特公司 | 2019-06-21 | — | — | CN | disclosed |