Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.55 |
| ▸ | MAPT | P10636 | 10/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 7/20 | 0.55 |
| ▸ | LMNA | P02545 | 6/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.55 |
| ▸ | HTT | P42858 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.48 |
| ▸ | SLC12A5 | Q9H2X9 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4380589 | 0.93 | ALDH1A1 (0.54) | ALDH1A1MAPTMAPK1LMNATDP1 | |
| SCHEMBL4377264 | 0.92 | ALDH1A1 (0.56) | ALDH1A1MAPTMAPK1LMNATDP1 | |
| SCHEMBL4378301 | 0.81 | ALDH1A1 (0.55) | ALDH1A1MAPTMAPK1LMNATDP1 | |
| SCHEMBL4379024 | 0.80 | ALDH1A1 (0.57) | ALDH1A1MAPTMAPK1LMNATDP1 | |
| SCHEMBL4375429 | 0.80 | ALDH1A1 (0.53) | ALDH1A1MAPTMAPK1LMNATDP1 | |
| SCHEMBL4375447 | 0.78 | ALDH1A1 (0.55) | ALDH1A1MAPTMAPK1LMNATDP1 | |
| SCHEMBL13090297 | 0.77 | MAPT (0.59) | ALDH1A1MAPTMAPK1LMNATDP1 | |
| SCHEMBL2830951 | 0.77 | MAPT (0.59) | ALDH1A1MAPTMAPK1LMNATDP1 | |
| SCHEMBL6606220 | 0.76 | ALDH1A1 (0.67) | ALDH1A1MAPTMAPK1LMNATDP1 | |
| SCHEMBL23852127 | 0.75 | ALDH1A1 (0.62) | ALDH1A1MAPTMAPK1LMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | claimed |
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | disclosed |
| US-7064135-B2 | Substituted piperidines | NOVO NORDISK INC. (DK) | 2006-06-20 | — | — | US | disclosed |