Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.63 |
| ▸ | CA12 | O43570 | 1/20 | 0.62 |
| ▸ | CA9 | Q16790 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | NAMPT | P43490 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | STAT3 | P40763 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | NT5E | P21589 | 1/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28309716 | 0.85 | NAMPT (0.64) | LMNAKDM4ENAMPTSMN1; SMN2KMT2A | |
| SCHEMBL10035672 | 0.82 | ENPP1 (0.69) | LMNACA12CA9KDM4ESMN1; SMN2 | |
| SCHEMBL29013030 | 0.77 | LMNA (1.00) | LMNAKDM4EL3MBTL1NAMPTSMN1; SMN2 | |
| SCHEMBL11555650 | 0.77 | LMNA (0.41) | LMNACA12CA9L3MBTL1SMN1; SMN2 | |
| SCHEMBL14716526 | 0.77 | KDM4E (1.00) | LMNAKDM4EL3MBTL1NAMPTSMN1; SMN2 | |
| SCHEMBL11554280 | 0.76 | LMNA (0.40) | LMNACA12CA9L3MBTL1SMN1; SMN2 | |
| SCHEMBL12228179 | 0.75 | KDM4E (0.73) | LMNACA12CA9KDM4EL3MBTL1 | |
| SCHEMBL28048024 | 0.75 | CA1 (0.60) | LMNACA12CA9KDM4ESMN1; SMN2 | |
| SCHEMBL5473602 | 0.75 | KDM4E (0.73) | LMNACA12CA9KDM4EL3MBTL1 | |
| SCHEMBL163194 | 0.74 | NAMPT (1.00) | LMNAKDM4EL3MBTL1NAMPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110078735-A | Pyrrolopyrimidine compounds with anti-tumor activity and application thereof | 河北医科大学 | 2019-08-02 | — | — | CN | disclosed |