Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 6/20 | 0.53 |
| ▸ | PORCN | Q9H237 | 2/20 | 0.40 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.38 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 2/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2833088 | 0.89 | GRM5 (0.56) | GRM5PORCNSMARCA2SMARCA4MAPT | |
| SCHEMBL2826318 | 0.88 | GRM5 (0.54) | GRM5PORCNSMARCA2SMARCA4NPC1 | |
| SCHEMBL2831334 | 0.88 | GRM5 (0.54) | GRM5PORCNSMARCA2SMARCA4NPC1 | |
| SCHEMBL2833093 | 0.87 | GRM5 (0.69) | GRM5PORCNSMARCA2SMARCA4 | |
| SCHEMBL2827034 | 0.86 | GRM5 (0.51) | GRM5PORCNSMARCA2SMARCA4 | |
| SCHEMBL2832198 | 0.86 | GRM5 (0.52) | GRM5PORCNSMARCA2SMARCA4 | |
| SCHEMBL2826714 | 0.85 | GRM5 (0.70) | GRM5PORCNSMARCA2SMARCA4MAPT | |
| SCHEMBL2833058 | 0.85 | GRM5 (0.52) | GRM5PORCNSMARCA2SMARCA4ALDH1A1 | |
| SCHEMBL2828392 | 0.85 | GRM5 (0.52) | GRM5PORCNSMARCA2SMARCA4MAPT | |
| SCHEMBL2828969 | 0.85 | GRM5 (0.52) | GRM5PORCNSMARCA2SMARCA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |