Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 7/20 | 0.54 |
| ▸ | PORCN | Q9H237 | 2/20 | 0.39 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.38 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | POLQ | O75417 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2829033 | 0.91 | GRM5 (0.44) | GRM5SMARCA2SMARCA4CYP1A2CYP3A4 | |
| SCHEMBL2833088 | 0.90 | GRM5 (0.56) | GRM5PORCNSMARCA2SMARCA4CYP3A4 | |
| SCHEMBL2826716 | 0.90 | GRM5 (0.50) | GRM5PORCNSMARCA2SMARCA4KMT2A | |
| SCHEMBL2826318 | 0.89 | GRM5 (0.54) | GRM5PORCNSMARCA2SMARCA4KMT2A | |
| SCHEMBL2833093 | 0.88 | GRM5 (0.69) | GRM5PORCNSMARCA2SMARCA4KMT2A | |
| SCHEMBL2828969 | 0.88 | GRM5 (0.52) | GRM5PORCNSMARCA2SMARCA4KMT2A | |
| SCHEMBL2828392 | 0.88 | GRM5 (0.52) | GRM5PORCNSMARCA2SMARCA4KMT2A | |
| SCHEMBL2831342 | 0.88 | GRM5 (0.53) | GRM5PORCNSMARCA2SMARCA4CYP3A4 | |
| SCHEMBL2829130 | 0.87 | GRM5 (0.51) | GRM5PORCNSMARCA2SMARCA4KMT2A | |
| SCHEMBL2832198 | 0.87 | GRM5 (0.52) | GRM5PORCNSMARCA2SMARCA4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |