Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.51 |
| ▸ | SLC13A5 | Q86YT5 | 10/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.47 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL2075184 | 0.98 | SLC13A5 (0.67) | SLC13A5ALDH1A1CYP2C9CYP1A2CYP2D6 | |
| Citric Acid SCHEMBL21219125 | 0.98 | SLC13A5 (0.67) | SLC13A5ALDH1A1CYP2C9CYP1A2CYP2D6 | |
| Citric Acid SCHEMBL27373095 | 0.96 | SLC13A5 (0.65) | SLC13A5ALDH1A1CYP2C9CYP1A2CYP2D6 | |
| Citric Acid SCHEMBL27805619 | 0.91 | SLC13A5 (0.64) | SLC13A5ALDH1A1CYP2C9CYP1A2CYP2D6 | |
| Biphenyl SCHEMBL27373094 | 0.86 | SLC13A5 (0.55) | SLC13A5ALDH1A1CYP2C9CYP1A2CYP2D6 | |
| Citric Acid SCHEMBL1550236 | 0.86 | ALDH1A1 (0.88) | SLC13A5ALDH1A1CYP1A2CYP2D6LMNA | |
| Citric Acid SCHEMBL6600942 | 0.85 | ALDH1A1 (0.62) | SLC13A5ALDH1A1CYP1A2CYP2D6LMNA | |
| Citric Acid SCHEMBL27466879 | 0.85 | SLC13A5 (0.61) | SLC13A5ALDH1A1CYP2C9 | |
| Citric Acid SCHEMBL5064884 | 0.83 | ALDH1A1 (0.60) | SLC13A5ALDH1A1CYP1A2CYP2D6LMNA | |
| Citric Acid SCHEMBL21145048 | 0.83 | ALDH1A1 (0.60) | SLC13A5ALDH1A1CYP1A2CYP2D6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110177592-A | Inhaler and airflow adaptor for inhaler | 诺尔顿沃特福德有限公司 | 2019-08-27 | — | — | CN | disclosed |