Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ANPEP | P15144 | 1/20 | 0.33 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.33 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.33 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tert-Butyl Formate SCHEMBL27998227 | 0.85 | TDP1 (0.43) | TDP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| Tert-Butyl Formate SCHEMBL27904056 | 0.84 | ALDH1A1 (0.41) | TDP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| Tert-Butyl Formate SCHEMBL27997975 | 0.84 | TDP1 (0.42) | TDP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| Tert-Butyl Formate SCHEMBL28025116 | 0.84 | TDP1 (0.42) | TDP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| Tert-Butyl Formate SCHEMBL27600872 | 0.84 | TDP1 (0.42) | TDP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| Tert-Butyl Formate SCHEMBL27718748 | 0.84 | TDP1 (0.42) | TDP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| Tert-Butyl Formate SCHEMBL27721169 | 0.84 | TDP1 (0.42) | TDP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| Tert-Butyl Formate SCHEMBL27906317 | 0.83 | TDP1 (0.45) | TDP1MEN1KMT2AALDH1A1MAPT | |
| Tert-Butyl Formate SCHEMBL28088768 | 0.83 | TDP1 (0.41) | TDP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| Tert-Butyl Formate SCHEMBL27766288 | 0.81 | TDP1 (0.46) | TDP1MEN1KMT2ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110177786-A | Pyrazolo [1,5-A] pyridine compounds being substituted are as RET kinase inhibitor | 阿雷生物药品公司 | 2019-08-27 | — | — | CN | disclosed |