Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Pyrrolidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CXCR4 | P61073 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyrrolidine SCHEMBL4604231 | 0.97 | ALDH1A1 (0.50) | ALDH1A1CXCR4SMN1; SMN2 | |
| Piperidine SCHEMBL1583028 | 0.94 | ALDH1A1 (0.56) | ALDH1A1CXCR4SMN1; SMN2 | |
| Piperidine SCHEMBL1288276 | 0.91 | ALDH1A1 (0.53) | ALDH1A1CXCR4SMN1; SMN2 | |
| Pyrrole SCHEMBL6427563 | 0.90 | — | — | |
| Pyrrole SCHEMBL28257456 | 0.88 | CXCR4 (0.56) | ALDH1A1CXCR4SMN1; SMN2 | |
| Pyrrole SCHEMBL28636726 | 0.87 | — | — | |
| Piperazine SCHEMBL28257898 | 0.83 | HIF1A (0.46) | CXCR4SMN1; SMN2 | |
| Piperazine SCHEMBL20360553 | 0.83 | HIF1A (0.46) | CXCR4SMN1; SMN2 | |
| Piperazine SCHEMBL28237390 | 0.80 | HIF1A (0.43) | CXCR4SMN1; SMN2 | |
| Piperazine SCHEMBL28087044 | 0.80 | HIF1A (0.43) | CXCR4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110036947-A | Method for inducing coral floating wave larvae to improve adhesive force | 深圳信息职业技术学院 | 2019-07-23 | — | — | CN | disclosed |